Optimal Pregnancy Environment Risk Assessment

OPERA is an international, interdisciplinary program of women’s health researchers, care providers, foundations and international agencies dedicated to discovering and disseminating inexpensive and accessible tools to diagnose those women at risk for preterm birth (PTB) or other adverse pregnancy outcome as early as possible in pregnancy and to promoting effective interventions to mitigate these risks. OPERA’s initial efforts will focus on risk diagnosis in populations of vulnerable women in any jurisdiction. An initiative of the Preterm Birth International Collaborative (PREBIC), OPERA receives support from the Worldwide Universities Network (WUN) and the March of Dimes (MOD) and is recognized by the World Health Organization (WHO).


OPERA intends to build a sustainable international organization that will provide guidance and support for studies of cohorts of pregnant women in order to develop evidence to 1) determine how to assess risk for preterm birth and other adverse pregnancy outcomes simply, inexpensively and as early as possible in pregnancy, 2) to identify the women in the highest (20%) at-risk group (with 80% precision), and 3) to share this information with other studies, care-providers and interested parties. OPERA is not a funding organization but instead provides support in terms of special skills, study design, data evaluation and sharing, guidance, advocacy, informs about best practices and communicates discoveries and achievements to partners and target audiences.


The purpose of this meeting will be to discuss and generate enthusiasm to achieve the goals of OPERA, to appreciate why early assessment of risk is important, to identify what is meant by populations of vulnerable women and to listen to some of their stories, to hear about mechanisms of risk and what we can learn from them regarding development of risk assessment tools, to learn more about the studies in progress and how they are assessing risk for preterm birth and other adverse pregnancy outcomes, to identify a few intervention strategies that may mitigate risks, and to discuss how to move the OPERA agenda forward toward a sustainable program that provides genuine benefit for women, their babies and care providers.